Methods This phase I clinical trial was conducted at the Department of Pharmacology, Faculty of Medicine, University of Colombo, Sri Lanka. Thirty healthy adults were recruited for the study, conducted for a period of 3 months, with the dose of CZ (water extract) increased at monthly intervals (85 mg, 250 mg and 500 mg). Data collection was carried out at baseline and during each monthly follow up visit. Anthropometric, clinical and biochemical assessments were done at baseline and during follow up.
Adverse effects and drug compliance was also evaluated. Results Twenty eight subjects completed the three months follow up. Mean age was 38.8 ± 10.4 years and 50% were males. There were no significant changes in the anthropometric parameters during the three months follow up. Both systolic and diastolic blood pressure reduced significant during the 1st month and this reduction was sustained throughout follow up. Full blood count, renal function tests, liver function tests, fasting blood glucose, HDL-c, VLDL-d and triglycerides remained within the normal range without any significant alteration during the 3 months. A significant reduction in the TC ( p.
Cinnamon, the inner bark of a tropical evergreen tree has two main varieties, Cinnamomum cassia ( Cinnamomum aromaticum) and Cinnamomum zeylanicum (CZ) [ ]. In Ayurvedic medicine Cinnamon is considered as a treatment for many ailments, including those of the respiratory, digestive and gynecological systems.
Bandung merupakan kota yang selalu menarik untuk dijadikan tujuan perjalanan atau mungkin hanya sekedar diperbincangkan. Bagi anda yang ingin menjelajah kota Bandung sudah sepantasnya berbekal peta, selain peta fisik alangkah lebih mudahnya jika anda juga memiliki peta dalam bentuk softcopy -nya, tinggal diunduh ke gadget dan anda pun siap menyusuri Bandung hingga ke gang-gang rahasianya.
Cinnamomum zeylanicum, also known as Ceylon cinnamon (the source of its Latin name, zeylanicum) or ‘true cinnamon’ is indigenous to Sri Lanka and Southern parts of India. Sri Lanka (formerly known as Ceylon) produces the largest quantity and the best quality CZ. Preparation of cinnamon involves stripping of the outer bark of the tree and letting the inner bark to dry and curl up into its customary cinnamon quills, it is available in the market either in its whole quill form (Cinnamon sticks) or as ground powder [ ]. At present both Cinnamon cassia and CZ are sold as preventative/therapeutic supplements for many ailments including, metabolic syndrome, insulin resistance, type 2 diabetes, hyperlipidaemia and arthritis [ ]. It is marketed either as a tablet/capsule or as different items of food fortified with cinnamon, including cinnamon biscuits, tea and sweets. One important difference between ‘true’ cinnamon and the cassia cinnamon is their coumarin content [ ]. The coumarin content in CZ appears to be very small to cause health risks, whereas the coumarin level in Cinnamomum aromaticum appears to be much higher and may pose health risks if consumed in higher quantity on a regular basis [ ].
Mindray DS USA, Inc. The Spectrum®/Spectrum OR™ Service Manual is intended as a guide for technically qualified personnel during repair and calibration procedures. This publication may have been updated to reflect product design changes and/or manual improvements. 3-channel thermal recorder with selectable high resolution printing formats: std 3 lead, rhythm lead, 3/2 leads or manual 1 lead 80mm folded or rolled thermosensitive paper with effective 72mm width.
The usage of Cassia cinnamon as a regular supplement with meals was not advocated or the daily dosage was restricted in many countries due to the toxic effects of Cinnamomum aromaticum on the liver and coagulation [ ]. In contrast CZ has shown to contain a lesser content of coumarin [, ], and thus it may be possible that CZ could be used in higher doses without toxic effects for longer durations. A recent systematic review summarized the medicinal properties of CZ [ ].
The authors concluded that, the available in-vitro and in-vivo evidence suggests that CZ has anti-microbial, anti-parasitic, anti-oxidant and free radical scavenging properties. In addition the authors also indicated that CZ seems to lower blood glucose, serum cholesterol and blood pressure, suggesting beneficial cardiovascular effects [ ]. However they noted the absence of properly conducted randomized controlled human trials, to decide on efficacy and safety of long term CZ use in humans and to determine whether these effects have public health implications. Animal studies on CZ has not demonstrated any significant adverse effects or toxicity on the liver, kidney and the pancreas [ ]. However, it is necessary to conduct well planned safety studies in humans, prior to advocating regular use of CZ for any medicinal benefit.